Functional and anatomical assessment of coronary artery disease based on intravascular optical coherence tomography

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K12846
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 90130:Medical systems-related
• Research Institution: Wakayama Medical University
• Principal Investigator: Kubo Takashi 和歌山県立医科大学, 医学部, 博士研究員 (30316096)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 画像診断

Outline of Final Research Achievements

This study has developed a technique for calculating the physiological severity of coronary artery disease based on the anatomical information of the coronary artery obtained from the intravascular optical coherence tomography (OCT). OCT was able to estimate changes in blood flow in coronary artery lesions by the ability to automatically measure the area of the lumen. In addition, OCT was able to evaluate in detail the histopathological characteristics of arteriosclerotic plaques at high risk of developing acute myocardial infarction. The results of this study suggest that OCT can accurately diagnose myocardial ischemia in angina pectoris and improve the prediction accuracy of acute myocardial infarction.

Free Research Field

循環器内科

Academic Significance and Societal Importance of the Research Achievements

本研究が発展させた血管内画像診断の新たな解析手法により、胸痛の強度や性情などの主観的判定にたよってきた狭心症診断の客観的判定が可能になる。客観的で正確な狭心症の診断は、真に治療介入を必要とする症例の同定につながり、適正な医療を導くことができる。また、急性心筋梗塞の発症を高い精度で予知できれば、治療介入することによる発症の予防・人々の生活の質や生命予後の改善・医療経済負担の軽減に貢献できると期待される。