2021 Fiscal Year Final Research Report

Development of a completely non-invasive real-time imaging blood flow measuring device capable of various measurements

Research Project

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Project/Area Number	19K12855
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 90130:Medical systems-related
Research Institution	National Institute of Technology, Toyama College
Principal Investigator	Akiguchi Shunsuke 富山高等専門学校, その他部局等, 准教授 (50462130)
Co-Investigator(Kenkyū-buntansha)	田尻智紀富山高等専門学校, その他部局等, 講師 (10735525) 安東嗣修金城学院大学, 薬学部, 教授 (50333498) 経田僚昭富山高等専門学校, その他部局等, 准教授 (50579729) 八賀正司公立小松大学, 保健医療学部, 教授 (80123305)
Project Period (FY)	2019-04-01 – 2022-03-31
Keywords	非侵襲計測装置 / 血流計測装置 / 音響光学素子
Outline of Final Research Achievements	This research project is to develop a completely non-invasive real-time imaging blood flow measuring device capable of various measurements using laser beams. The three themes of "real-time imaging," "in vivo blood flow velocity direction information," and "measurement area expansion" were established and addressed. For "real-time imaging," we confirmed that processing is possible in less than 10 ms for 64 channels, which is the current projected maximum measurement range. For "in vivo blood flow direction information," we constructed an optical system that includes an AOM and confirmed it could successfully perform measurements using flow paths and blood in which the flow direction has been changed. In the "measurement area expansion" section, we constructed a system in which the measurement area was expanded from a point to a plane.
Free Research Field	生体医工学
Academic Significance and Societal Importance of the Research Achievements	本装置で取得できる血流情報は血液検査のように抜き出した静的な情報ではなく、実際に生体内を今まさに流れている血流を動的に計測するため、血液検査とは異なる情報を獲得できる。この計測結果を瞬時に、さらにイメージング画像などのわかりやすい形で出力できれば応用範囲が劇的に広がる。さらに従来装置では不可能であった血流の流れ方向も新たな情報として取得できれば動脈静脈の判断も可能となる。この装置の特性を生かせば、血管新生と関連が深い癌の早期発見、日焼けなどによる炎症の血流計測、血管内の血栓観察、微細領域の血流分布観測など、多様な計測への応用が期待できる。