2021 Fiscal Year Final Research Report
Evaluation of the degree of muscle fatigue to exercise performed by school physical education for children with Duchenne muscular dystrophy
| Project/Area Number |
19K12862
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 90140:Medical technology assessment-related
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中村 昭則 信州大学, 医学部, 特任教授 (10303471)
濃沼 政美 帝京平成大学, 薬学部, 教授 (50385978)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 唾液中乳酸 / 代謝 |
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| Outline of Final Research Achievements |
The validity of measuring salivary lactate(SLA)with a simple device and the relationship between salivary lactate and blood lactate(BLA)were tested. The results showed that the ICC (2,1) for each subject between the Lactate Pro 2 and the autoanalyzer in the device test was 0.568-0.763, with an overall ICC of 0.773 (95% confidence interval: 0.678 to 0.844, p < 0.01). For the relationship between the two, the cross-correlation coefficient was 0.535 for lag 0 and 0.750 for lag 1, indicating that SLA lagged behind BLA by one measurement minute (5 minutes). It was verified that the use of the existing simple device was reasonable and that the trends for blood and saliva were similar to previous studies.
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| Free Research Field |
神経筋疾患
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| Academic Significance and Societal Importance of the Research Achievements |
現行の測定手法とLactate Pro 2の測定値には高い妥当性が確認され、SLAを臨床現場で非侵襲的に測定できることが示唆された。本研究はDMD児で唾液乳酸を使用する前段階の研究であったが，必要な事項は全て検証され論文化された．本研究の結果より，DMD児に限らず多くの患者においてトレーニング後の筋の代謝を評価する際に，既存の簡易デバイスを使用して唾液乳酸を指標とすることができ，その値が担保されたと提言できたことが学術的および社会的に意義がある．
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