Elucidation of the mechanism of appetite from the Perspective of circadian clock system and Intestinal Microbiota

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K14018
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 08030:Family and consumer sciences, and culture and living-related
• Research Institution: Waseda University
• Principal Investigator: Haraguchi Atsushi 早稲田大学, 理工学術院, 講師(任期付) (80834671)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 腸内細菌叢 / 糞便移植 / 水溶性食物繊維 / マウス / 食欲

Outline of Final Research Achievements

We examined the effects of improvement of the intestinal environment by soluble fiber intake on appetite. We confirmed that a high-fat diet containing resistant maltodextrin (RM-HFD), a soluble dietary fiber, decreased food intake and improved the intestinal environment. Furthermore, when fecal microbiota from the mice feeding with RM-HFD were transplanted into other mice, the transplanted mice showed low HFD intake. Although we observed no effects of RM-HFD on appetite from the viewpoints of circadian clock system, the results suggest that soluble fiber intake may be involved in the suppression of excessive appetite.

Free Research Field

時間栄養学

Academic Significance and Societal Importance of the Research Achievements

本研究課題の成果は、腸内細菌叢・腸内環境の改善が嗜好性の高い食べ物に対する過剰な食欲(本研究では高脂肪食に対する過剰な食欲)の抑制につながる可能性を示唆する基礎的データであり、今後のヒト栄養を考える上での基礎的情報となり得ると考えている。今後さらなる検証が必要ではあるが、本研究ではヒト応用の部分も踏まえて水溶性食物繊維の含有量を決定していることから、ダイエットが必要な肥満患者などに対して食欲を抑制するための新たなターゲットとなることが期待される。