2022 Fiscal Year Final Research Report
Characteristics of GRP that cause severe fruit allergy
Project/Area Number |
19K14040
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 08030:Family and consumer sciences, and culture and living-related
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Research Institution | Ryukoku University |
Principal Investigator |
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Project Period (FY) |
2019-04-01 – 2023-03-31
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Keywords | 果物アレルギー / 食物アレルギー / コンポーネント解析 / 果物ー花粉アレルギー症候群 |
Outline of Final Research Achievements |
Gibberellin regulated protei (GRP) has attracted attention as an allergen that causes severe fruit allergy, but its details have not been elucidated. In this study, we clarified foods that GRP-allergic patients should be careful of by analyzing cross-reactivity using monoclonal antibody (mAb) techniques. Subsequently, we found a method for reducing allergenicity of GRP, which is known to cause symptoms even in heated fruit. Furthermore, by purifying various GRPs other than peach and apple, which have been successful so far, and preparing novel anti-GRP mAb, we have established a foundation for comprehensive immunological analysis of GRPs.
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Free Research Field |
食生活学
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Academic Significance and Societal Importance of the Research Achievements |
これまでの食物アレルギー治療は原因食品を食べない「徹底的な原因食物の除去」が主であったが、現在は食べられる範囲までは食べる「必要最小限の除去」が推奨されている。そのため、アレルゲンをタンパク質レベルで解析する「コンポーネント解析」は、効果的な治療や安全・安心な喫食のために欠かせない。本研究では、重篤な果物アレルギーの原因として注目されているGRPについて、GRPアレルギー患者が注意すべき食品を明らかにすることができた。また、今回見出したアレルゲン性を低下させる方法を応用できれば、GRPアレルギー患者が果物を安心して食べられる可能性を広げることができると考える。
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