2021 Fiscal Year Final Research Report
Development of a physics-based fast screening method for detecting the cancer-therapeutic peptides
| Project/Area Number |
19K14674
|
|---|
| Research Category |
Grant-in-Aid for Early-Career Scientists
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
Basic Section 13040:Biophysics, chemical physics and soft matter physics-related
|
|---|
| Research Institution | Niigata University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2019-04-01 – 2022-03-31
|
| Keywords | ペプチド抗癌剤 / 天然変性ペプチド / 自由エネルギー計算 / 水和自由エネルギー / 積分方程式理論 / 形態計測学的アプローチ |
|---|
| Outline of Final Research Achievements |
This study aims to design and synthesis of the peptide-based drug candidates which bind strongly to the MDM2 oncoprotein. We developed a theoretical method to calculate the free energy change upon protein-peptide bindings with sufficient accuracy and remarkably high speed. The physicochemical origins of the MDM2-peptide binding were clarified and, base on these findings, the novel candidates of peptide drug were synthesized. We further developed a rapid physics-based method to identify a native structure of a protein-peptide complex.
|
| Free Research Field |
生物物理
|
| Academic Significance and Societal Importance of the Research Achievements |
本研究の成果により、「ペプチド薬剤探索の飛躍的な高速化」に向けた基礎研究が大きく進展した。これにより、多くの新薬候補の創出が期待できる、という学術的意義を持つ。
さらに本研究の成果は、生体機能の分子レベルでの究明・制御を基盤とする、「次世代の生体医工学」研究領域の開拓へ貢献している。これにより、様々な疾病原因の解明から治療薬・予防法の開発に至る、我が国のライフサイエンス推進と「健康長寿社会」の構築に大きく貢献できる、という社会的意義を持つ。
|
