Intra-body sensing system with the integration of nanoparticle and microdevice technology

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K15416
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 28050:Nano/micro-systems-related
• Research Institution: The University of Tokyo
• Principal Investigator: Takehara Hiroaki 東京大学, 大学院工学系研究科(工学部), 講師 (60723088)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: マイクロニードル / 生体吸収性ポリマー

Outline of Final Research Achievements

In this research, we investigated low-invasive intra-body sensing system for improving quality of life in patients. Micromolding process accompanied with controlling crystallinity of polymer materials was developed for fabricating microdevices, especially those used in the body. Poly(L-lactide) (PLLA) microneedles were fabricated based on the developed fabrication processes. As a proof-of-concept, the capability of device system was shown using blood-vessel embedded skin phantom models.

Free Research Field

バイオデバイス

Academic Significance and Societal Importance of the Research Achievements

少子高齢化により増大し続ける医療コストは喫緊に解決すべき社会的課題となっており、Point of Care Testing (POCT)の概念に基づく小型診断機器の重要性が高まっている。本研究で得られた成果は、患者個人レベルでの精密な医療や超早期診断といった医療技術へ貢献する新たな小型診断機器の実現に繋がるものであると期待する。