2020 Fiscal Year Final Research Report
Study on the mechanism of carbon-induced signal enhancement in inductively coupled plasma mass spectrometry
| Project/Area Number |
19K15607
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 34020:Analytical chemistry-related
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
Tomoko ARIGA 国立研究開発法人産業技術総合研究所, 計量標準総合センター, 主任研究員 (40784111)
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| Project Period (FY) |
2019-04-01 – 2021-03-31
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| Keywords | 誘導結合プラズマ質量分析法 / ICP-MS / 炭素増感効果 / マトリクス効果 / 有機溶剤 / 多原子イオン |
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| Outline of Final Research Achievements |
This study revealed that significant carbon-induced signal enhancement is a phenomenon specific to elements existing as element-containing molecules (i.e., oxoacids) in the sample solutions (i.e., P, As, Se, and I). From the detailed investigation in which As was chosen as a representative element characterized by carbon-induced signal enhancement, the following pathway can be assumed as one mechanism of carbon-induced signal enhancement of As+: carbon which is derived from organic solvents enhances the formation of AsO+ derived from the decomposition of As-containing molecules (i.e., arsenious acid).
Consequently, the signal of As+, part of which is presumably derived from the dissociation of the AsO+, is enhanced.
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| Free Research Field |
分析化学
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| Academic Significance and Societal Importance of the Research Achievements |
有機溶剤効果は、ICP-MSを用いた有機溶剤分析において精確な定量分析の妨げとなることから、抑制や補正が必要であるものの、その発生メカニズムについては未だ不明な点が多く有効な抑制・補正手法が確立されていないのが現状である。本研究は、研究対象をAsに限定して有機溶剤効果の具体的な発生メカニズムに関する知見を得たが、同様のメカニズムは他の増感元素(Se, P, I)でも推測されることから、本研究成果は有機溶剤効果発生のメカニズムに関して重要な情報を提供した。今後メカニズムの解明がさらに進むことで、有機溶剤効果の有効な抑制・補正手法の確立に繋がることが期待される。
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