Studies on structurally complex natural products using chemical reactions

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K15706
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
• Research Institution: Yokohama City University
• Principal Investigator: Irie Raku 横浜市立大学, 理学部, 助教 (50835238)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 海洋天然物 / 構造解析 / 分解反応 / アミド結合

Outline of Final Research Achievements

Poecillastrins, isolated from marine sponges, are potent inhibitors of a V-ATPase, a membrane protein involved in osteoporosis and cancer growth and metastasis. However, the chemical structure of poecillastrins has not been fully elucidated, which has hindered the application of them in molecular tools and pharmaceuticals. In this study, the large and structurally complex natural products, poecillastrins, were successfully degraded into smaller fragments for structural analysis.

Free Research Field

天然物化学

Academic Significance and Societal Importance of the Research Achievements

本研究ではポエシラストリンの応用研究への第一歩である構造決定に大きく近づくことができた。また今回着目した化学構造は他の有用化合物にも見られるため、本研究で見出した反応は同様の構造解析を志向した化学分解や構造活性相関研究にあたり有効な手法となりうる。