Elucidation of novel preventive effect of food factors on hyperglycemia via muscle hypertrophy

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K15780
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 38050:Food sciences-related
• Research Institution: Konan Women's University
• Principal Investigator: Yoshioka Yasukiyo 甲南女子大学, 医療栄養学部, 助教 (80801513)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 緑豆ペプチド / 糖取り込み促進 / 筋肥大促進

Outline of Final Research Achievements

We examined a novel anti-hyperglycemic effect focusing on the relationship between the promotion of protein synthesis and glucose uptake in muscle. It was found that the peptides obtained from the metabolite of mung bean protein promoted protein synthesis in C2C12 myotubes and glucose uptake in L6 myotubes. This mechanism of mung bean peptides on glucose uptake was mediated by activation of insulin-like pathway, AMPK pathway and Jak2/Stat3 pathway. Molecular probes of mung bean peptides were prepared to search target molecules in myotubes. Leptin receptor was identified as a candidate molecule. From these results, it was suggested that targeting the leptin receptor and finding a food factor showing a leptin-like action contributes to the prevention of hyperglycemia.

Free Research Field

食品機能学

Academic Significance and Societal Importance of the Research Achievements

日本では、食の欧米化やライフスタイルの変化により、生活習慣病の罹患者および予備軍が増加し、この解消が急務である。その中でも、高血糖および糖尿病に対する抑制効果に関する研究は世界中で行われている。本研究では、骨格筋における肥大と糖取り込みに着目し、高血糖予防効果の標的としてレプチンレセプターを見出した。この成果は、新たな機能性食品因子の発見だけでなく、既存の機能性食品因子と共作用させることで、相加的な効果が期待できる。