Anti-aging effect of food components via the regulation of chemosensory receptors expressed to dermal fibroblast.

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K15792
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 38050:Food sciences-related
• Research Institution: University of Shizuoka
• Principal Investigator: Terada Yuko 静岡県立大学, 食品栄養科学部, 助教 (80767632)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 化学感覚受容体 / 皮膚老化 / 皮膚線維芽細胞 / コラーゲン産生 / 嗅覚受容体 / 天然物

Outline of Final Research Achievements

The mRNA expression of 434 kinds of chemosensory receptors in the human normal dermal fibroblast was comprehensively analyzed by RT-PCR. The analysis showed that 13 of them were expressed at a high level. Receptor ligands for these receptors were screened using the receptors-expressing HEK cells and their anti-aging activity was tested on the human dermal fibroblast. Geraniol, a rose fragrance, was suggested to induce collagen synthesis via the activation of OR1A1, an olfactory receptor. Molecular biological analysis indicated that TGFb/smad signal, one of the representative collagen synthesis pathways, was activated by geraniol.

Free Research Field

食品化学

Academic Significance and Societal Importance of the Research Achievements

本研究の遂行により、バラの香気成分であるゲラニオールが、皮膚線維芽細胞に発現する嗅覚受容体の一種OR1A1の活性化を介して、コラーゲン産生を促進させる可能性が示された。皮膚コラーゲンの減少は、シワ、シミの原因となることから、皮膚老化の抑制において、コラーゲン量を増加させることが重要である。本成果は、香り成分を活用した新たな機能性食品、化粧品、薬剤等への開発へとつながることが期待される。