Construction and Application of the Matrix Library for Standardization of Pretreatment Method for Health Food Products Containing Pharmaceutical Ingredients

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K15802
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 38050:Food sciences-related
• Research Institution: Osaka Institute of Public Health
• Principal Investigator: Takeda Akihiro 地方独立行政法人 大阪健康安全基盤研究所, 衛生化学部, 主任研究員 (00622755)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: いわゆる健康食品 / 医薬品成分 / QuEChERS法

Outline of Final Research Achievements

Health foods illegally containing pharmaceutical ingredients have been distributed, and health hazard have occurred as a result of ingesting such health foods. Health foods contain many matrices, and there is a risk of overlooking the pharmaceutical ingredients contained in them. In this study, we considered creating a “matrix library” that consolidates information on the matrices that appear when analyzing health foods. Therefore, we analyzed 81 samples of health foods, identified 329 matrices, and compiled the removal rates of each matrix by for different pretreatment methods into a matrix library In addition, the usefulness of the matrix library was confirmed through addition-recovery test.

Free Research Field

分析化学

Academic Significance and Societal Importance of the Research Achievements

コーヒーや、ハチミツなど食品そのものに医薬品成分が配合される事例が近年増加している。そのため、過去に経験のないマトリックスによる分析の妨害を受けるため、日常分析の手法では対応できず、前処理法を適宜検討する必要があった。前処理法の情報とマトリックスの分析データをまとめたマトリックスライブラリにより、複雑な予備検討を必要とせず、最適な前処理法を開発することが可能となり、健康食品中の医薬品成分を誤りなく検出及び定量できることが期待できる。