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2022 Fiscal Year Final Research Report

Elucidation of a new regulatory mechanism for the regulation of female sexual behavior: Focusing on novel estrogen-responsive peptides

Research Project

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Project/Area Number 19K15966
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 42010:Animal production science-related
Research InstitutionNippon Veterinary and Life Science University (2020-2022)
Nippon Medical School (2019)

Principal Investigator

Watanabe Youki  日本獣医生命科学大学, 応用生命科学部, 助教 (50781788)

Project Period (FY) 2019-04-01 – 2023-03-31
Keywordsロードシス / エストロジェン
Outline of Final Research Achievements

In this study, I aimed to unravel the neural mechanism governing estrous behavior in female rats. To achieve this, I focused on identifying potential factors responsible for regulating estrous behavior by conducting an analysis of genes associated with estrogen receptor α (ERα) in the ventromedial hypothalamus, a crucial nucleus involved in the control of estrous behavior. Among the various candidates, the gene encoding neuropeptide B (NPB) emerged as the most candidate. Utilizing the GONAD technique, we successfully obtained neuropeptide B receptor 1 (Npbwr1) knockout candidate rats (F0) from five pregnant rats, then seven rats exhibiting the desired genetic modification.

Free Research Field

神経内分泌

Academic Significance and Societal Importance of the Research Achievements

本研究により、ニューロペプチドB(NPB)の脳室内投与は、発情行動制御に関連のあるホルモン、黄体形成ホルモンやプロラクチン分泌の分泌を亢進することが明らかとなった。この結果は、生殖機能の中枢制御機構の全容解明への一助となりうる。また、本実験では、発情行動発現を制御する因子の同定にまでは至らなかったが、本研究で作出したNpbwr1遺伝子欠損ラットは、今後、NPB-NPBWR1シグナリングが発情行動に及ぼす影響を明らかにするために用いるだけでなく、摂食機能や生殖機能などの生理機能におけるNPB/NPW-Npbwr1の役割を詳細に解明するために有用なツールとなることが期待される。

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Published: 2024-01-30   Modified: 2025-01-30  

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