Identification of environmental factors that affect the anesthetic susceptibility and its association with epigenetics

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K16030
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 42040:Laboratory animal science-related
• Research Institution: Azabu University
• Principal Investigator: Tsukamoto Atsushi 麻布大学, 獣医学部, 准教授 (00647175)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 麻酔 / エピジェネティクス / Refinement

Outline of Final Research Achievements

In this study, we investigated the influence of environmental factors on the sensitivity of anesthetic agent, and assessed its mechanism in rodents. The growing environment, especially the stress level and the interaction of individuals influences the sensitivity of anesthetic agent in rodents. It is suggested that changes of gene expression pattern in spinal cord and hippocampus is involved in the difference of anesthetic sensitivity.

Free Research Field

実験動物医学

Academic Significance and Societal Importance of the Research Achievements

麻酔薬に対する感受性差は実験動物学分野や医療分野における麻酔管理の重要課題となっている。本研究で得られた知見は、げっ歯類における麻酔管理の向上に寄与するとともに、人医療における麻酔感受性差の機序解明の一助となるものと考えられる。