Identification of novel cell-to-cell signaling substances in yeast stress response and their effects on proliferation

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K16070
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 43030:Functional biochemistry-related
• Research Institution: The University of Tokyo
• Principal Investigator: Oda Arisa 東京大学, 大学院総合文化研究科, 助教 (00760084)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 酵母 / ストレス応答

Outline of Final Research Achievements

In this study, a phenomenon called " latecomer killing" was observed. We found that yeast cells releases several stress responsive toxins that poisoned other microorganisms when adapting to a glucose depleted environment. These toxins can also have effect on the yeast cell growth, but cells which produced the toxins acquired resistance to them. Behavior of secreting toxins which can also kill its own clonal cells during critical survival situation of glucose starvation seems risky. But when the cells which had already adapted to glucose starvation and toxins, they can keep food resources for themselves as the toxins inhibit growth of "latecomer" microorganisms.

Free Research Field

生物科学

Academic Significance and Societal Importance of the Research Achievements

本研究では、酵母の集団レベルでの適応を観察することで、細胞間相互作用を介した生存戦略を理解することを目指した。その結果、ストレス環境下で、酵母が自身のリニエージの生存に有利なように環境中に物質を分泌することがわかった。この研究は、従来報告されてきた細胞内の応答と同時に、酵母自身による環境変化も取り扱うことで、より高次な酵母の環境適応現象の理解へとつながった。