Clarification of the functions of striatal direct and indirect pathways that regulate behavior in dependence on the environment.

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K16264
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 46010:Neuroscience-general-related
• Research Institution: Fukushima Medical University
• Principal Investigator: Nishizawa Kayo 福島県立医科大学, 医学部, 助教 (30644108)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 背側線条体 / 直接路 / 間接路 / 弁別学習

Outline of Final Research Achievements

The dorsal striatum, which contains the dorsolateral striatum (DLS) and dorsomedial striatum (DMS), regurates the discrimination learning. However, the mechanism of striatal direct pathways derived from DLS or DMS in discrimination learning remains unclear. In this study, we investigated and developed the basic technology necessary to clarify this mechanism.

Free Research Field

神経科学

Academic Significance and Societal Importance of the Research Achievements

本研究において我々は、直接路の選択的除去に必要な基盤技術開発に成功した。この様な弁別学習を媒介する背側線条体のニューロンタイプを同定した上での機能の解明は現在までになく、本研究によって得られた知見は、パーキンソン病を代表する高次機能障害に対する新しい治療法の確立につながる事が期待される。