2023 Fiscal Year Final Research Report
Investigation of the ameliorative effect of inhalation of plant-derived fragrances on sleep-disordered stress
| Project/Area Number |
19K16400
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 47050:Environmental and natural pharmaceutical resources-related
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| Research Institution | Toho University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2024-03-31
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| Keywords | アロマセラピー / 睡眠障害 / ストレス |
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| Outline of Final Research Achievements |
ICR male mice were subjected to sleep deprivation stress for 24 hours to create a mouse model of sleep disturbance. In this mouse model, anxiety-like behavior was observed in the elevated plus-maze test, and serum corticosterone and dual specificity phosphatase 1, a candidate gene for stress marker in the brain, were increased. As a result, inhalation of sesame oil aroma showed a decrease in anxiety-like behavior and each stress marker mentioned above. In order to identify the active ingredients, the components of sesame oil aroma were inhaled. As for the single component, anxiolytic effects were observed in the 2,5-dimethylpyrazine and 2-methoxy phenol group. These results suggest that these molecules may be powerful anti-stress agents.
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| Free Research Field |
健康科学、神経科学、行動薬理学
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| Academic Significance and Societal Importance of the Research Achievements |
睡眠障害の患者数は近年急増しており、うつ病や不安症状も付随することからQOLの低下に大きく影響している。睡眠薬による長期服用時の依存性や筋弛緩、記憶障害等の副作用が社会問題化となり、より効果的かつ安全性の高い治療法の確立が社会から求められている。本実験で用いた睡眠障害モデルマウスでは、ヒトの症状に近い不安様行動や、血中および脳内のストレスマーカーの上昇が認められた。これら異常に対してセサミオイルの吸入は有意な改善効果を示しており、服用方法も経口投与や腹腔内投与と比較して非侵襲的であることから、睡眠障害患者の中で特に大きい割合を示す高齢者に対しても有効な対処法となることが期待できる。
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