2022 Fiscal Year Final Research Report
Analysis of adipocyte differentiation by Integrator complex
| Project/Area Number |
19K16542
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 49010:Pathological biochemistry-related
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | IntS6 / Integrator Complex / 全身性脂肪萎縮症 / 遺伝子転写調節 / メタボリック症候群 / 糖尿病 / 脂肪肝 |
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| Outline of Final Research Achievements |
In this research, we succeeded the development of adipose specific IntS6 conditional knockout mouse which exhibit poor development of adipose tissue, hyperglycemia, and poor weight gain in high fat diet mimic the congenital lipodystrophy syndrome. Our results implicate that the regulation of gene expression by Integrator Complex is essential for the differentiation and maintenance of adipocyte and adipose tissue, and could be the treatment target of Diabetes mellitus and Metabolic syndrome.
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| Free Research Field |
病態医化学
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| Academic Significance and Societal Importance of the Research Achievements |
我々はさまざまな組織ででIntS6というタンパク質を欠失させることのできるマウスの作成に成功しました。本研究ではその中で脂肪細胞のみでIntS6を欠損させることに成功し、そのマウスでは脂肪組織の萎縮、高血糖、脂肪肝といった、代謝異常を呈することが明らかとなり、IntS6やIntegrator complex が糖尿病やメタボリックシンドロームといった疾患の新たな治療ターゲットとなる可能性があることがわかりました。
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