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2020 Fiscal Year Annual Research Report

Molecular Pathogenesis of Follicular Lymphoma and its early/precursor lesions

Research Project

Project/Area Number 19K16554
Research InstitutionUniversity of Yamanashi

Principal Investigator

大石 直輝  山梨大学, 大学院総合研究部, 准教授 (90623661)

Project Period (FY) 2019-04-01 – 2021-03-31
Keywords濾胞性リンパ腫 / ISFN
Outline of Annual Research Achievements

① リンパ節郭清を受けた非リンパ腫患者340症例を対象に、in situ follicular neoplasm (ISFN)のスクリーニングをおこなった。検索したリンパ節は合計5700個 (1症例あたり1-81個)、うち胚中心を含むリンパ節の合計3685個(1症例あたり平均10.8個)であった。このなかで、7例のISFNが同定された。したがって、現時点の検討で、ISFNの頻度は2.0%と推定される。
② 7例のISFNは、男性4例、女性3例であり、年齢中央値は60歳(範囲45-80歳)であった。経過観察期間の中央値は59ヶ月(範囲47-68ヶ月)で、濾胞性リンパ腫への進展は認められなかった。免疫組織化学による検討で、胚中心に限局したCD20+/CD10+/BCL6+/BCL2+/Ki67 lowの細胞集団が確認された。また、FISHによる検討で、BCL2遺伝子のsplitが観察された。
③ 上記ISFNについては、レーザーキャプチャー・マイクロダイセクションのうえDNA/RNAの抽出をおこなった。十分な量のDNAを抽出できたのは5例で、これらの遺伝子異常をwhole-exome sequencingで解析した。現在、sequencing dataを解析中である。
④ 一方、RNAについては十分な量を抽出できず、遺伝子発現解析をおこなうことができなかった。
⑤ 本研究によって、本邦におけるISFNの頻度、臨床像、遺伝子異常を統合的に解析でき、国際学術誌への投稿を準備している。

  • Research Products

    (12 results)

All 2021 2020

All Journal Article (12 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 12 results,  Open Access: 1 results)

  • [Journal Article] Early Transformation to Classic Hodgkin Lymphoma in a Chemotherapy-na?ve Chronic Lymphocytic Leukemia Patient upon Initial Treatment with Ibrutinib2021

    • Author(s)
      Koshiishi Megumi、Odate Toru、Nakagawa Yukie、Suzuki Jun、Kumagai Takuya、Kawashima Ichiro、Yamamoto Takeo、Nakajima Kei、Tanaka Masaru、Oishi Naoki、Kondo Tetuso、Kirito Keita
    • Journal Title

      Internal Medicine

      Volume: - Pages: -

    • DOI

      10.2169/internalmedicine.6979-20

    • Peer Reviewed
  • [Journal Article] Heme activates platelets and exacerbates rhabdomyolysis-induced acute kidney injury via CLEC-2 and GPVI/FcRγ2021

    • Author(s)
      Oishi Saori、Tsukiji Nagaharu、Otake Shimon、Oishi Naoki、Sasaki Tomoyuki、Shirai Toshiaki、Yoshikawa Yuri、Takano Katsuhiro、Shinmori Hideyuki、Inukai Takeshi、Kondo Tetsuo、Suzuki-Inoue Katsue
    • Journal Title

      Blood Advances

      Volume: 5 Pages: 2017~2026

    • DOI

      10.1182/bloodadvances.2020001698

    • Peer Reviewed
  • [Journal Article] Expression of CD1 molecules and colony‐stimulating factor 1 receptor in indeterminate cell histiocytosis2021

    • Author(s)
      Kinoshita Manao、Ogawa Youichi、Honobe Akiko、Tomita Ozumi、Oishi Naoki、Shimada Shinji、Kondo Tetsuo、Kawamura Tatsuyoshi
    • Journal Title

      The Journal of Dermatology

      Volume: - Pages: -

    • DOI

      10.1111/1346-8138.15857

    • Peer Reviewed
  • [Journal Article] Progression of Papillary Thyroid Carcinoma to Anaplastic Carcinoma in Metastatic Lymph Nodes: Solid/Insular Growth and Hobnail Cell Change in Lymph Nodes Are Predictors of Subsequent Anaplastic Transformation2021

    • Author(s)
      Odate Toru、Oishi Naoki、Kawai Masataka、Tahara Ippei、Mochizuki Kunio、Akaishi Junko、Ito Koichi、Katoh Ryohei、Kondo Tetsuo
    • Journal Title

      Endocrine Pathology

      Volume: - Pages: -

    • DOI

      10.1007/s12022-021-09674-1

    • Peer Reviewed
  • [Journal Article] High‐grade uterine sarcoma with osteosarcomatous differentiation arising from a MED12‐ mutated leiomyoma, a case report2021

    • Author(s)
      Le Minh‐Khang、Omori Makiko、Oishi Naoki、Oi Megumi、Fukasawa Hiroko、Hirata Shuji、Kondo Tetsuo
    • Journal Title

      Pathology International

      Volume: 71 Pages: 199~203

    • DOI

      10.1111/pin.13065

    • Peer Reviewed
  • [Journal Article] Genetic differences in follicular thyroid carcinoma between Asian and Western countries: a systematic review2020

    • Author(s)
      Odate Toru、Oishi Naoki、Vuong Huy Gia、Mochizuki Kunio、Kondo Tetsuo
    • Journal Title

      Gland Surgery

      Volume: 9 Pages: 1813~1826

    • DOI

      10.21037/gs-20-356

    • Peer Reviewed
  • [Journal Article] Assessment of MGMT methylation status using high-performance liquid chromatography in newly diagnosed glioblastoma2020

    • Author(s)
      Hanihara Mitsuto、Miyake Kunio、Watanabe Atsushi、Yamada Yuriko、Oishi Naoki、Kawataki Tomoyuki、Inukai Takeshi、Kondo Tetsuo、Kinouchi Hiroyuki
    • Journal Title

      Clinical Epigenetics

      Volume: 12 Pages: -

    • DOI

      10.1186/s13148-020-00968-5

    • Peer Reviewed / Open Access
  • [Journal Article] Nodal EBV-positive polymorphic B cell lymphoproliferative disorder with plasma cell differentiation: clinicopathological analysis of five cases2020

    • Author(s)
      Satou Akira、Tabata Tetsuya、Suzuki Yuka、Sato Yasuharu、Tahara Ippei、Mochizuki Kunio、Oishi Naoki、Takahara Taishi、Yoshino Tadashi、Tsuzuki Toyonori、Nakamura Shigeo
    • Journal Title

      Virchows Archiv

      Volume: 478 Pages: 969~976

    • DOI

      10.1007/s00428-020-02967-6

    • Peer Reviewed
  • [Journal Article] Loss of 5-Hydroxymethylcytosine is an Epigenetic Hallmark of Thyroid Carcinomas with TERT Promoter Mutations2020

    • Author(s)
      Oishi Naoki、Vuong Huy Gia、Mochizuki Kunio、Kondo Tetsuo
    • Journal Title

      Endocrine Pathology

      Volume: 31 Pages: 359~366

    • DOI

      10.1007/s12022-020-09652-z

    • Peer Reviewed
  • [Journal Article] Identification of Recurrent TERT Promoter Mutations in Intrathyroid Thymic Carcinomas2020

    • Author(s)
      Tahara Ippei、Oishi Naoki、Mochizuki Kunio、Oyama Toshio、Miyata Kazuyuki、Miyauchi Akira、Hirokawa Mitsuyoshi、Katoh Ryohei、Kondo Tetsuo
    • Journal Title

      Endocrine Pathology

      Volume: 31 Pages: 274~282

    • DOI

      10.1007/s12022-020-09635-0

    • Peer Reviewed
  • [Journal Article] Molecular profiling reveals a hypoxia signature in breast implant-associated anaplastic large cell lymphoma2020

    • Author(s)
      Oishi Naoki、Hundal Tanya、Phillips Jessica L.、et al.
    • Journal Title

      Haematologica

      Volume: - Pages: -

    • DOI

      10.3324/haematol.2019.245860

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Composite monoclonal B‐cell lymphocytosis andMYD88L265P‐positive lymphoplasmacytic lymphoma in a patient with IgM light chain amyloidosis: Case report2020

    • Author(s)
      Oishi Naoki、Inoue Tomohiro、Odate Toru、Mochizuki Kunio、Ohashi Kenichi、Kirito Keita、Kondo Tetsuo
    • Journal Title

      Pathology International

      Volume: 70 Pages: 458~462

    • DOI

      10.1111/pin.12937

    • Peer Reviewed

URL: 

Published: 2022-03-04  

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