2022 Fiscal Year Final Research Report
Development of a novel predicting factor for anaplastic transformation with the recurrent thyroid cancer
Project/Area Number |
19K16583
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 49020:Human pathology-related
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Research Institution | National Cancer Center Japan (2022) University of Yamanashi (2019-2021) |
Principal Investigator |
Odate Toru 国立研究開発法人国立がん研究センター, 中央病院, がん専門修練医 (20813249)
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Project Period (FY) |
2019-04-01 – 2023-03-31
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Keywords | 甲状腺 / 未分化癌 / 乳頭癌 / 未分化癌転化 / BRAF / TERT / 病理学 |
Outline of Final Research Achievements |
Most anaplastic thyroid carcinomas (ATCs) arise from papillary thyroid carcinoma (PTC). This process is also called anaplastic transformation, and the morphological harbingers of this phenomenon in nodal recurrence have not been assessed systematically. For this reason, the current study focused on features of 10 PTCs with regional lymph node recurrence that was accompanied with disease progression due to anaplastic transformation in at least one of the nodal recurrences. The findings of additional 19 PTCs which recurred without anaplastic transformation after 10 years of follow-up served as the control group.This series identified a subset of recurrent PTCs with TERT promoter mutation was prone to undergo anaplastic transformation, and that solid, insular growth and hobnail cell features were morphological predictors of anaplastic transformation in the nodal recurrence.
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Free Research Field |
人体病理学
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Academic Significance and Societal Importance of the Research Achievements |
甲状腺乳頭癌は予後の良い癌である一方で未分化癌は生存期間中央値がせいぜい9ヶ月程度とされる非常に予後の悪い癌である。本研究では乳頭癌再発を繰り返す患者において未分化癌転化を起こしやすい患者群を明らかにすることによって、これらハイリスクグループに属する患者群を抽出し、より厳重なフォローアップを行うなどの日常臨床への対応方法に関する根拠を与えた。
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