Study for mechanisms underlying microbiota-mediated modulation of cytotoxic T cells

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K16698
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 49070:Immunology-related
• Research Institution: Keio University
• Principal Investigator: TANOUE Takeshi 慶應義塾大学, 医学部(信濃町), 講師 (60732972)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 腸内細菌

Outline of Final Research Achievements

In the recent decade, plenty of evidence showed Specific members of gut microbiota can affect gut immune system especially for helper T cells. However it is still unknown for the relationship of gut microbiota and CD8-positive T cells. Here, we addressed the effect of microbiota on cytotoxic T cells by analyzing granzyme-producing CD8 T cells. We analyze the intestinal localization of granzyme-producing cell and effect of microbiota by using germ-free and gnotobiotic mice and showed that specific members of microbiota can induce the granzyme-producing CD8 T cells.

Free Research Field

免疫学　微生物学

Academic Significance and Societal Importance of the Research Achievements

本研究で特定した細菌株の定着によりGranzyme産生誘導機能を活用して感染症やがん治療に応用出来る可能性が考えられた。また学術的には、これまでにGranzyme産生を誘導する腸内細菌を体系的に精査した報告は無く、本研究はそのさきがけに相当する研究であると考えられる。