2023 Fiscal Year Final Research Report
Epigenomic analysis of the induction of apoptosis
| Project/Area Number |
19K16726
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 50010:Tumor biology-related
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
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| Project Period (FY) |
2020-03-01 – 2024-03-31
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| Keywords | 上皮間葉転換 / 癌 / クロマチン動態 |
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| Outline of Final Research Achievements |
Epithelial-mesenchymal transition (EMT) is a phenomenon in which epithelial cells change to become mesenchymal-like cells. This phenotypic change is known to be a coordinated change in the expression of a wide variety of genes and proteins.However, the molecular mechanism involved in EMT is unclear.
In this study, we analyzed EMT mechanism using normal cells as a model for EMT induction. We also planned to find the differences by comparing by OSCC with normal cells.
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| Free Research Field |
分子生物学
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| Academic Significance and Societal Importance of the Research Achievements |
上皮間葉転換(EMT)は、創傷治癒、細胞/組織の線維化、癌の転移/浸潤に関与することが報告されている。その分子機序を明らかにすることは学術的意義を満たすだけでなく、これら現象に課題を解決させることで社会的意義も満たすことができる。
本研究の成果は上皮系細胞が後天的/一時的にフェノタイプ変化を起こす現象、並びにその制御する分子機序の理解を深め、創傷治癒の課題である瘢痕化の抑制や口腔癌の転移/浸潤を抑制する新規治療法の提案につながると考えている。
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