Analysis of lipid metabolism via LSR and anti-tumor effect of anti-LSR antibody in ovarian cancer

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K16748
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 50010:Tumor biology-related
• Research Institution: Osaka University
• Principal Investigator: HIRAMATSU Kosuke 大阪大学, 医学部附属病院, 助教 (10650591)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 卵巣癌 / LSR / 子宮体癌

Outline of Final Research Achievements

(1) LSR expression in LSR-positive cells was higher in hypoxic environment and glucose deprivation compared with normal culture. (3) LDL and VLDL did not induce cell migration of LSR-positive cells.
(4) In endometrial cancer which is one of the gynecologic cancer same as ovarian cancer, high expression of LSR was significantly poor prognostic factor. Especially, LSR strongly related to myometrial invasion and distant metastasis. LSR promoted MAPK pathway and subsequent cell proliferation. Furthermore, LSR promoted expression of MMP2 and Mt1-MMP which are related to EMT and contributed cell invasion. Finally, anti-LSR antibody inhibited theses processes.

Free Research Field

婦人科腫瘍

Academic Significance and Societal Importance of the Research Achievements

卵巣癌においてLSRは低酸素や低Glcといった環境下での細胞の増殖/生存に関わることが示唆された。また同時に検証した子宮体癌におけるLSRの機能は、卵巣癌と同様に細胞の増殖の促進であり、今回新たにEMTに関連するMMP2の発現がLSRと関連することが証明され、LSRが卵巣癌と子宮体癌の増殖、浸潤、遊走に深くかかわることが示唆された。