2022 Fiscal Year Final Research Report
Dopamine receptors and the brain circuits responsible for memory modification
Project/Area Number |
19K16882
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 51010:Basic brain sciences-related
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Research Institution | Waseda University (2021-2022) Tokyo Medical and Dental University (2020) Tohoku University (2019) |
Principal Investigator |
TERAO Kanta 早稲田大学, 文学学術院, その他(招聘研究員) (90825449)
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Project Period (FY) |
2019-04-01 – 2023-03-31
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Keywords | 記憶 / 学習 / ドーパミン / コオロギ / ショウジョウバエ / 消去 |
Outline of Final Research Achievements |
When a discrepancy between memory and reality is found, it is important to modify memories and act in accordance with reality. Given the importance of the dopamine system in associative learning in mammals and insects, we attempted to test the hypothesis that the dopamine system contributes to memory modification in insects as well. As a result of this study, we found that the extinction and overexpectation effects, which are experiments for memory modification, can be demonstrated in crickets. This is the first demonstration of the overexpectation effect in invertebrates and we reported it in a journal. We obtain preliminary results on the function of the dopamine system in the extinction and overexpectation effects, thus further studies are required.
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Free Research Field |
神経行動学
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Academic Significance and Societal Importance of the Research Achievements |
記憶の修正機能の破綻は、依存症やPTSD (心的外傷後ストレス障害) 、統合失調症や強迫神経症など多数の精神疾患に繋がる。したがって、その検証のための行動実験系と神経メカニズムの解明が必要である。 消去は依存症やPTSDの原因の一端であると共に、その治療にも用いられてきた。本研究で明らかにした消去とその類型である過剰予期効果の性質は、将来的には、これらの治療の基盤となることが期待される。
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