Development of diagnostic software using perfusion imaging for post-stroke epilepsy

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K16888
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 51010:Basic brain sciences-related
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Fukuma Kazuki 国立研究開発法人国立循環器病研究センター, 病院, 医師 (20820674)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 脳卒中 / てんかん / SPECT

Outline of Final Research Achievements

We have developed an imaging diagnostic method for detecting hyperperfusion using postictal single-photon emission computed tomography in patients with poststroke epilepsy.
We also investigated clinical features of nonmotor onset seizures in poststroke epilepsy. The nonmotor onset seizure type accounted for 43% of PSE cases, and 67% of patients had no subsequent convulsions. Poststroke hemiparesis, frontal lobe, and putaminal stroke lesions were negative indicators of non-MOS. Postictal single-photon emission computed tomography revealed hyperperfusion in the temporal lobe more frequently in the non-motor onset seizure group than in the motor onset seizure group.

Free Research Field

脳卒中学　てんかん学

Academic Significance and Societal Importance of the Research Achievements

脳卒中後てんかんにおいて、発作後遷延性過灌流がみられることを初めて明らかにし、その画像診断法を開発した。脳卒中後てんかんは、けいれんやてんかん性脳波異常波を認めない場合には、診断が困難となる。非運動起始発作を呈する患者において、発作後過灌流が高率に検出されることが明らかとなり、補助診断としての灌流画像の有用性が期待される。