2021 Fiscal Year Final Research Report
Role of the reward circuit for decision process: a functional analysis in monkey ventral striatum
| Project/Area Number |
19K16890
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 51020:Cognitive and brain science-related
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 腹側線条体 / 意思決定 / 報酬選択 / 神経活動 / 電気刺激 / シグナルダイナミクス |
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| Outline of Final Research Achievements |
Decision-making is an essential component of animal survival strategies. The information of reward-value is an important for the process of decision-making.We found not only value-selective neurons, but also chosen-value-selective and choice-selective neurons in the ventral striatum of the monkey for the decision-making period. Additionally, these signals were found before onset of the choice behavior.Furthermore, we found the behavioral effects of electrical stimulation in the ventral striatum, which appeared only for fluctuated decision-making. These results suggest that the monkey's ventral striatum is involved in the process of decision-making from value to choice.
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| Free Research Field |
神経生理学
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| Academic Significance and Societal Importance of the Research Achievements |
ドーパミン入力を受ける腹側線条体はモチベーションや薬物などの依存行動に関わる領域として知られているが、本研究では意思決定過程に関わるサル腹側線条体の機能に着目した実験を行い、サル腹側線条体が意思決定に関わる多様なシグナルをコードし、選択傾向が固定されていない不安定な選択条件下の選択行動に対してサル腹側線条体の神経活動が因果的関係性を示すことが明らかとなった。これらの結果は、報酬選択場面において腹側線条体の神経活動が直接的に意思決定シグナルの調節に関わることを示唆しており、本研究により意思決定過程に関わるサル腹側線条体の機能の一端を明らかにできた。
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