2021 Fiscal Year Final Research Report
Identification of novel autoantibody for heat shock protein disrupting the blood-brain barrier and its clinical application.
| Project/Area Number |
19K16917
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 51030:Pathophysiologic neuroscience-related
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 血液脳関門 / ストレス蛋白質 / 視神経脊髄炎 |
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| Outline of Final Research Achievements |
The purpose of this project is to discovery the new autoantibody, which cause the blood-brain barrier (BBB) disruption from patients with neuromyelitis optica (NMO) using our human in vitro BBB model. We discovered new antibodies that target a heat shock protein on the surface of cerebral vascular endothelial cells which decreased the barrier function of the in vitro BBB model and its titer was found to be elevated at the onset and recurrence of NMO, and was associated with the severity of the disease. Assessment of antibody titer to this heat shock protein in NMO patients may be useful as a molecular marker to monitor the disease course of NMO.
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| Free Research Field |
臨床神経学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究で，視神経脊髄炎の流血中や脳脊髄液中の熱ショック蛋白質に対する自己抗体が血液脳関門の破綻に直接関与すること，および本抗体価が疾患の病勢を反映することを初めて明らにした．熱ショック蛋白質に対する抗体は，病勢をモニターする分子マーカとなる可能性があり，本抗体の作用を人為的に阻止する新たな治療標的として有望である．
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