2021 Fiscal Year Final Research Report
Analysis between RNA modification and pathogenesis in myelodysplastic syndromes
Project/Area Number |
19K16988
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 52010:General internal medicine-related
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Research Institution | International University of Health and Welfare |
Principal Investigator |
Shibuta Tatsuki 国際医療福祉大学, 福岡保健医療学部, 講師 (20799192)
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Keywords | 骨髄異形成症候群 / RNA修飾 |
Outline of Final Research Achievements |
Cytosine methylation in mRNA and RNA methyltransferases in myelodysplastic syndrome (MDS) were analyzed. Compared to CD34-positive cells, MDS cells showed increased expression of transcription factors and granulocyte lineage-specific genes, and increased methylated cytosine in the untranslated region. In addition, NSUN2, which is a RNA methyltransferase, was highly expressed in MDS cells, and its expression level was involved in cell proliferatin.
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Free Research Field |
病態検査学
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Academic Significance and Societal Importance of the Research Achievements |
MDSには芽球比率による病期が存在するが、NSUN2 mRNAがMDSでの病期を推測するための病態進展マーカーとして有用となり、侵襲性の高い検査の回避や検査者の習熟が必要な形態診断を補助できる可能性が高い。 またNSUN2阻害剤によりMDSの進展を抑制できる可能性があり、今後さらに検討する必要がある。
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