2021 Fiscal Year Final Research Report
Elucidation of the pathomechanisms of microglial diseases with severe neuropsychiatric symptoms and search for treatment options.
| Project/Area Number |
19K17065
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 52030:Psychiatry-related
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| Research Institution | Asahikawa Medical College (2021)
Nagoya City University (2019-2020) |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | ミクログリア / ALSP / HDLS / 精神神経疾患 |
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| Outline of Final Research Achievements |
Microglia play various roles in the brain, and their dysfunction causes microglial disease, which presents with severe neuropsychiatric symptoms. This study aims to analyze microglial dysfunctions at the cellular level using the human peripheral blood-induced microglia-like cell technology developed by the applicant, to elucidate the pathomechanisms of microglial diseases and to search for novel therapeutic strategies.
As a result of this research, blood samples were taken from actual HDLS patients, and analysis of the microglia-like cells produced revealed that they were different compared to healthy subjects. In addition, they found similar changes in clinical samples in microglial cells from mouse brains and in model cells generated using siRNA. The paper is currently being submitted for publication.
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| Free Research Field |
精神神経科学
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| Academic Significance and Societal Importance of the Research Achievements |
学術的意義：本研究によって、原因不明のミクログリア病として知られていたHDLSの病態機序の一端が明らかになった。
社会的意義：本研究によって、将来的にミクログリアの特定の分子を標的とした治療法開発の可能性が示唆された。
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