Changes of neuroinflammatory and oxidative stress blood markers during ECT in schizophrenia and mood disorders

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K17094
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52030:Psychiatry-related
• Research Institution: Wakayama Medical University
• Principal Investigator: Okuhira Kazuya 和歌山県立医科大学, 医学部, 助教 (70644087)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 電気けいれん療法 / 再発 / 気分障害 / 統合失調症 / 炎症・酸化ストレスマーカー

Outline of Final Research Achievements

We investigated changes in peripheral blood inflammation and oxidative stress markers during ECT.The inflammatory marker sIL-2R decreased during ECT.Anti-inflammatory EPA and DHA increased during ECT.The antioxidant stress marker 25OH-VitD increased during ECT.
These results suggest the anti-inflammatory and antioxidant stress effects of ECT.

Free Research Field

精神医学

Academic Significance and Societal Importance of the Research Achievements

本研究の結果はECTの抗炎症作用、抗酸化ストレス作用を示唆しており、統合失調症と気分障害におけるECTは、生物学的に抗炎症作用、抗酸化ストレス作用を介して、精神症状の影響を与える可能性がある。
この研究成果は電気けいれん療法の再発予測因子に至る重要な知見となりうる。