New diagnostic method for Parkinson's disease by multimodal imaging

2022 Fiscal Year Annual Research Report

• Project/Area Number: 19K17244
• Research Institution: Juntendo University
• Principal Investigator: 鎌形 康司 順天堂大学, 医学部, 准教授 (60568153)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: パーキンソン病 / マルチモーダルMRI / 拡散MRI / Fixel based analysis / パーキンソニズム / 進行性核上性麻痺 / 大脳皮質基底核症候群

Outline of Annual Research Achievements

本研究課題の目的はマルチモーダルMRI解析を用いて、パーキンソン病（PD）診断評価法の開発とPD病態の神経基盤を解明することである。本年度は下記検討を行なった。
臨床的にPDと鑑別が課題となるパーキンソニズムである進行性核上性麻痺(PSP)と大脳皮質基底核症候群(CBS)を対象に、fixel based analysis (FBA)を用いた横断的・縦断的検討では、病理組織学的に示唆されているタウの伝播パターンと一致する線維密度の低下及びそれに続く線維萎縮という疾患進行パターンが明らかとなり、FBA指標が両疾患の病態評価及び鑑別に有用であることを示した(Uchida W, Kamagata K, et al. NPJ Parkinsons Dis. under review)。
また、PD病態への関与が報告されている脳クリアランスシステムの仮説であるグリンパティックシステム機能をMRIで評価する解析パイプラインを整備し、その有用性を示した (Kamagata K, et al. Neurology. 2022; Andica C, Kamagata K, et al. Neurobiol Dis. 2022; Morita Y, Kamagata K, et al. Front Neurol. 2022; Saito Y, Kamagata K, et al. Jpn J Radiol. 2023)。さらに、PDにおける大脳白質評価に有用である白質自動セグメンテーション手法や定量MRI技術についてのレビュー論文を発表した(Andica C, Kamagata K, et al. Anat Sci Int. 2023; Hagiwara A, Kamagata K, et al. Invest Radiol. 2023)。

Research Products

• [Int'l Joint Research] University College of London(英国)
  • Country Name: UNITED KINGDOM
  • Counterpart Institution: University College of London
• [Journal Article] MR Fingerprinting for Liver Tissue Characterization: A Histopathologic Correlation Study (2023)
  • Author(s): Fujita Shohei、Sano Katsuhiro、Cruz Gastao、Fukumura Yuki、Kawasaki Hideo、Fukunaga Issei、Morita Yuichi、Yoneyama Masami、Kamagata Koji、Abe Osamu、Ikejima Kenichi、Botnar Rene M.、Prieto Claudia、Aoki Shigeki
  • Journal Title: Radiology Volume: 306 Pages: 150～159
  • DOI: 10.1148/radiol.220736
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neuroimaging findings related to glymphatic system alterations in older adults with metabolic syndrome (2023)
  • Author(s): Andica Christina、Kamagata Koji、Takabayashi Kaito、Kikuta Junko、Kaga Hideyoshi、Someya Yuki、Tamura Yoshifumi、Kawamori Ryuzo、Watada Hirotaka、Taoka Toshiaki、Naganawa Shinji、Aoki Shigeki
  • Journal Title: Neurobiology of Disease Volume: 177 Pages: 105990～105990
  • DOI: 10.1016/j.nbd.2023.105990
  • Peer Reviewed / Open Access
• [Journal Article] Glymphatic system impairment in nonathlete older male adults who played contact sports in their youth associated with cognitive decline: A diffusion tensor image analysis along the perivascular space study (2023)
  • Author(s): Morita Y、Kamagata K、Andica C、Takabayashi K、Kikuta J、Fujita S、Samoyeau T、Uchida W、Saito Y、Tabata H、Naito H、Someya Y、Kaga H、Tamura Y、Miyata M、Akashi T、Wada A、Taoka T、Naganawa S、Watada H、Kawamori R、Abe O、Aoki S
  • Journal Title: Frontiers in Neurology Volume: 14 Pages: 1100736
  • DOI: 10.3389/fneur.2023.1100736
  • Peer Reviewed / Open Access
• [Journal Article] Multiparametric MRI: From Simultaneous Rapid Acquisition Methods and Analysis Techniques Using Scoring, Machine Learning, Radiomics, and Deep Learning to the Generation of Novel Metrics (2023)
  • Author(s): Hagiwara Akifumi、Fujita Shohei、Kurokawa Ryo、Andica Christina、Kamagata Koji、Aoki Shigeki
  • Journal Title: Investigative Radiology Volume: Publish Ahead of Print Pages: -
  • DOI: 10.1097/RLI.0000000000000962
  • Peer Reviewed / Open Access
• [Journal Article] Automated three-dimensional major white matter bundle segmentation using diffusion magnetic resonance imaging (2023)
  • Author(s): Andica Christina、Kamagata Koji、Aoki Shigeki
  • Journal Title: Anatomical Science International Volume: - Pages: -
  • DOI: 10.1007/s12565-023-00715-9
  • Peer Reviewed / Open Access
• [Journal Article] Multisite harmonization of diffusion tensor image analysis along the perivascular space using the COMBined Association Test (2023)
  • Author(s): Saito Yuya、Kamagata Koji、Andica Christina、Taoka Toshiaki、Tuerxun Rukeye、Uchida Wataru、Takabayashi Kaito、Owaki Mana、Yoshida Seina、Yamazaki Keigo、Naganawa Shinji、Aoki Shigeki
  • Journal Title: Japanese Journal of Radiology Volume: - Pages: -
  • DOI: 10.1007/s11604-023-01432-z
  • Peer Reviewed / Open Access
• [Journal Article] Improved reproducibility of diffusion tensor image analysis along the perivascular space (DTI-ALPS) index calculated by manual and automated methods (2023)
  • Author(s): Saito Yuya、Kamagata Koji、Uchida Wataru、Takabayashi Kaito、Aoki Shigeki
  • Journal Title: Japanese Journal of Radiology Volume: - Pages: -
  • DOI: 10.1007/s11604-023-01429-8
  • Peer Reviewed / Open Access
• [Journal Article] White matter fiber-specific degeneration in older adults with metabolic syndrome (2022)
  • Author(s): Andica Christina、Kamagata Koji、Uchida Wataru、Takabayashi Kaito、Shimoji Keigo、Kaga Hideyoshi、Someya Yuki、Tamura Yoshifumi、Kawamori Ryuzo、Watada Hirotaka、Hori Masaaki、Aoki Shigeki
  • Journal Title: Molecular Metabolism Volume: 62 Pages: 101527～101527
  • DOI: 10.1016/j.molmet.2022.101527
  • Peer Reviewed / Open Access
• [Journal Article] Association of MRI Indices of Glymphatic System With Amyloid Deposition and Cognition in Mild Cognitive Impairment and Alzheimer Disease (2022)
  • Author(s): Kamagata Koji、Andica Christina、Takabayashi Kaito、Saito Yuya、Taoka Toshiaki、Nozaki Hayato、Kikuta Junko、Fujita Shohei、Hagiwara Akifumi、Kamiya Kouhei、Wada Akihiko、Akashi Toshiaki、Sano Katsuhiro、Nishizawa Mitsuo、Hori Masaaki、Naganawa Shinji、Aoki Shigeki、for the Alzheimer's Disease Neuroimaging Initiative
  • Journal Title: Neurology Volume: 99 Pages: e2648～e2660
  • DOI: 10.1212/WNL.0000000000201300
  • Peer Reviewed / Open Access
• [Presentation] 拡散MRI：脳微細構造解析及び脳コネクトーム解析 (2022)
  • Author(s): 鎌形康司
  • Organizer: 2022年度生理学研究所研究会 多次元脳形態研究会
  • Invited
• [Presentation] Noninvasive magnetic resonance imaging measures of glymphatic system activity (2022)
  • Author(s): 鎌形康司
  • Organizer: 第40回日本神経治療学会学術集会
  • Invited
• [Presentation] Non-invasive MRI measurements of glymphatic system activity associated with CSF Aβ levels and FDG PET uptake in Alzheimer’s disease. ISMRM 30th annual meeting and exhibition (2022)
  • Author(s): Kamagata K, Andica C, Takabayashi K, Saito Y, Taoka T, Nozaki H, Kikuta J, Fujita S, Kamiya K, Wada A, Akashi T, Hori M, Naganawa S, Aoki S.
  • Organizer: ISMRM 30th annual meeting and exhibition
  • Int'l Joint Research
• [Presentation] Fixel-Based Analysis of White Matter Degeneration in Patients with Progressive Supranuclear Palsy and Corticobasal Syndrome. ISMRM 30th annual meeting and exhibition (2022)
  • Author(s): Uchida W, Kamagata K, Andica C, Saito Y, Takabayashi K, Hagiwara A, Fujita S, Akashi T, Wada A, Hori M, Aoki S
  • Organizer: ISMRM 30th annual meeting and exhibition
  • Int'l Joint Research
• [Presentation] Harmonization of multi-site DTI and NODDI data using the combined association test (2022)
  • Author(s): Saito Y, Kamagata K, Andica C, Uchida W, Nozaki H, Owaki M, Hagiwara A, Fujita S, Akashi T, Wada A, Hori M, Aoki S
  • Organizer: ISMRM 30th annual meeting and exhibition
  • Int'l Joint Research
• [Presentation] A structural connectivity approach to identify human paraventricular thalamic nucleus (2022)
  • Author(s): Kamagata K, Uchida W, Andica C, Nagai Y, Nishioka M, Owaki M, Saito Y, Takabayashi K, Hagiwara A, Wada A, Akashi T, Aoki S, Kato T
  • Organizer: 第50回日本磁気共鳴医学会大会
• [Presentation] Fiber-specific white matter changes in early-stage Parkinson's disease-linked glucocerebrosidase gene mutations (2022)
  • Author(s): Andica C, Kamagata K, Uchida W, Saito Y, Takabayashi K, Owaki M, Hagiwara A, Aoki S
  • Organizer: 第50回日本磁気共鳴医学会大会
• [Presentation] Impact of DTI metrics harmonization on multicenter Alzheimer's disease study (2022)
  • Author(s): Saito Y, Kamagata K, Andica C, Uchida W, Takabayashi K, Yoshida S, Owaki M, Hagiwara A, Fujita S, Wada A, Akashi T, Irie R, Shimoji K, Hori M, Aoki S
  • Organizer: 第50回日本磁気共鳴医学会大会
• [Presentation] Harmonization of multicenter DTI and NODDI data using ComBat and TSGLM (2022)
  • Author(s): Saito Y, Kamagata K, Andica C, Maikusa N, Uchida W, Takabayashi K, Yoshida S, Owaki M, Hagiwara A, Fujita S, Akashi T, Wada A, Irie R, Shimoji K, Hori M, Kamiya K, Koike S, Hayashi T, Aoki S
  • Organizer: 第50回日本磁気共鳴医学会大会
• [Presentation] Free-water Imaging in the white matter under Selegiline Treatment in Parkinson’s Disease (2022)
  • Author(s): Takeshige H, Hatano T, Kamagata K, Andica C, Ogawa T, Shindo A, Ucihda W, Shimo Y, Oyama G, Umemura A, Ito M, Hori M, Aoki S, Hattori N
  • Organizer: 第63回日本神経学会学術大会
• [Presentation] Striatal degeneration and Cerebellar fiber alterations of Parkinson’s disease (2022)
  • Author(s): Shindo A, Ogawa T, Hatano T, Shinichi U, Sako W, Kamagata K, Andica C, Takeshige H, Uchida W, Oyama G, Umemura A, Iwamuro H, Ito M, Nakanishi A, Murakami K, Aoki S, Hattori N
  • Organizer: 第63回日本神経学会学術大会
• [Presentation] White matter differences between MSA-P and MSA-C using fixel-based analysis (2022)
  • Author(s): Ogawa T, Hatano T, Kamagata K, Uchida W, Andica A, Takeshige H, Shindo A, Sako W, Shimo Y, Oyama G, Umemura A, Iwamuro H, Aoki S, Hattori N
  • Organizer: 第63回日本神経学会学術大会
• [Presentation] Relationship between subjective evaluation of Parkinson's disease and brain finestructure (2022)
  • Author(s): Kujirai H, Ogawa T, Shindo A, Takeshige H, Hatano T, Uchida W, Kamagata K, Aoki S, Hattori N
  • Organizer: 第63回日本神経学会学術大会
• [Presentation] MIBG cardiac scintigraphy may detect Frontal dysfunction in Parkinson's disease (2022)
  • Author(s): Okada H, Hatano T, Kamagata K, Takeshige H, Shindo A, Uchida W, Aoki S, Hattori N
  • Organizer: 第63回日本神経学会学術大会