Development of heart radioprotection with reduced coenzyme Q10

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K17267
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Kobe University
• Principal Investigator: Yasuyuki Shimizu 神戸大学, 医学部附属病院, 特命技術員 (80824234)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 放射線治療 / 放射線防護 / 還元型CoQ10 / 質量分析 / 脳

Outline of Final Research Achievements

There is an urgent need to improve the treatment outcome of malignant glioma, one of the most intractable malignant tumors. In cases where complete surgical resection is difficult, the combination of radiation therapy further increases the expectation for curative and long-term survival. On the other hand, adverse reactions of radiation to normal tissues may result in decreased quality of life, and sometimes, sufficient doses cannot be prescribed. Therefore, there is a need to develop a method to protect only normal tissues without degrading the therapeutic effect of radiation on tumors. In the present study, we aimed to verify whether reduced CoQ10, which has been shown to have radioprotective effects on the intestinal tract in our laboratory, can also exert radioprotective effects on the central nervous system.

Free Research Field

放射線腫瘍学

Academic Significance and Societal Importance of the Research Achievements

悪性神経膠腫には、MGMT やIDH1 などの分子病理的な予後不良因子に解析も発展しつつある
が、有害反応軽減への取組みは世界的にも稀有である。イメージング質量分による解析はこれまで未知で視覚する事が困難であった放射線照射による脳中のコエンザイムQ10 の酸化還元変化反応が実証できれば、放射線治療を受ける患者に有害反応のみを低減した新規治療戦略を提案できると考えた。