2022 Fiscal Year Final Research Report
An involvement of Toll-like receptor 9 signaling in the pathogenesis of post-infectious irritable bowel syndrome
| Project/Area Number |
19K17461
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53010:Gastroenterology-related
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| Research Institution | Shimane University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | 感染後過敏性腸症候群 |
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| Outline of Final Research Achievements |
Wild type (WT) and Toll-like receptor 9 Knock out (KO) mice were introduced acute gastroenteritis using Citrobacter rodentium. Barostat procedure, which is the standard IBS evaluation method, were performed 6 weeks after infection. Interestingly, only TLR9KO mice developed visceral hypersensitivity. We have further investigated the mechanisms, and we found it the upregulated bradykinin B2 receptor (BDKRB2) was involved in visceral hypersensitivity.
Therefore, we are going to elucidate if the BDKRB2 can be a new therapeutic target for developing PI-IBS.
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| Free Research Field |
消化器内科
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| Academic Significance and Societal Importance of the Research Achievements |
本研究から、Toll-like recepter9欠損状態に感染性腸炎を生じることが過敏性腸症候群の発症の一因であること、腸管知覚過敏の原因としてブラジキニンB2受容体の関与が示唆された。そのため今後ブラジキニンB2受容体をターゲットとした新規の治療法の開発が期待できると考える。
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