Vascular response after implantation of drug-eluting bioabsorbable magnesium stent

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K17535
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: Wakayama Medical University
• Principal Investigator: Ozaki Yuichi 和歌山県立医科大学, 医学部, 講師 (00507999)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: 薬剤溶出型生体吸収性マグネシウムステント / 血管応答 / 光干渉断層法

Outline of Final Research Achievements

By observing the bioabsorption process of a drug-eluting bioabsorbable magnesium stent using OCT, we were able to investigate problems with the absorption process and the occurrence of events after stent placement. We also investigated the effect of a drug-eluting bioabsorbable magnesium stent on side branch lesions using 3D-OCT, and its usefulness was confirmed. However, there are still many points that are unclear regarding the vascular response during the magnesium absorption process in vivo, and the appropriate metal absorption speed and drug elution speed are also considered to be future issues.

Free Research Field

冠動脈イメージング

Academic Significance and Societal Importance of the Research Achievements

薬剤溶出性生態吸収性マグネシウムステントの生体内吸収過程をOCTで観察することで臨床応用においてその有用性を確認することができた。
薬剤溶出型生体吸収性マグネシウムステント植え込み後の金属ストラット吸収過程における血管応答を明らかにすることでこれまでの冠動脈ステントの欠点をすべて克服する、いわば“究極の冠動脈ステント”となる可能性が高く、虚血性心疾患の治療を一変する可能性を秘めており、冠動脈疾患治療戦略に大きく貢献できると考える。