Assessment of long-term prognosis and mechanism of conduction system in patients with His-bundle pacing implantation in a multi-center study

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K17558
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: Nagoya University
• Principal Investigator: Yanagisawa Satoshi 名古屋大学, 医学系研究科, 特任講師 (30768578)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: ペースメーカ

Outline of Final Research Achievements

This prospective multi-center study was aimed to evaluate the efficacy and long-term prognosis in patients who underwent His-bundle pacing implantation. Approximately 70% of the patients had successful His-bundle pacing. After a follow-up period of 6-12 months, mean left ventricular ejection function and brain natriuretic peptide levels were improved from baseline. Most patients had a good clinical course with stable His-bundle pacing threshold and no clinical adverse events at the follow-up. Some population could not continue His-bundle pacing owing to an increased His pacing threshold.

Free Research Field

臨床電気生理学

Academic Significance and Societal Importance of the Research Achievements

本研究は、ヒス束ペースメーカを植え込んだ症例を前向きに多施設共同で検討を行い、長期にわたり観察を行ったものである。ヒス束ペースメーカの急性期の成功率や植え込み後の効果については、既存の報告と比較して遜色ない結果であることが示された。本研究の成果により、本邦でのヒス束ペースメーカの植え込みの実情と成績（安全性、効果）について示すことができた貴重な報告であると考える。