The change of myocardial blood flow after transcatheter aortic valve implantation

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K17573
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: Fukushima Medical University
• Principal Investigator: Kiko Takatoyo 福島県立医科大学, 医学部, 助手 (50814480)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: PET / MRI / Ammonia / 心筋血流

Outline of Final Research Achievements

We revealed the hybrid PET / MRI procedures using various PET tracers for aortic valve stenosis. In particular, the safety method of ammonia PET / MRI under vasodilator stress was established, and it has been possible to evaluate myocardial blood flow before transcatheter aortic valve implantation. If we have more cases, we could evaluate the improvement of myocardial blood flow after transcatheter aortic valve implantation. In addition, there were cases in which FDG PET and NaF PET accumulated in the aortic valve, suggesting the possibility of evaluation for vulnerable plaques in the aortic valve.

Free Research Field

心臓核医学

Academic Significance and Societal Importance of the Research Achievements

大動脈弁狭窄症に対する経カテーテル的大動脈弁植え込み術は、外科的手術と比較して低侵襲であるため、今後はより適応が広くなる可能性が高い。PET/MRI複合機を用いて心筋血流や解剖学的評価を同時に行うことによって、重症度の評価のみならず、治療効果判定を行うこともできる。また、遠隔期の心血管イベント発生の関連を検討し、大動脈弁狭窄症のどのような病態が予後不良か、病態に合わせた最適治療法など、リスクの層別化を詳細に行い治療方針の決定について有用となる可能性がある。