The mechanism of ventricular arrhythmia under global ischemia in HFpEF

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K17584
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: Hokkaido University
• Principal Investigator: Kamada Rui 北海道大学, 医学研究院, 特任助教 (60836104)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 心室性不整脈 / HFpEF / SKチャネル

Outline of Final Research Achievements

Relationship between arrhythmia under myocardial ischemia conditions and Small conductance calcium sensitive channels (SK channels) in the HFpEF model. Aphrodisiac by inducing total myocardial ischemia by hypoxic perfusion using a genetic hypertension model rat. It was confirmed that ventricular arrhythmia occurred in myocardial ischemia, but its inducibility was reduced by administration of apamin, which is a selective inhibitor of SK channels. Examination of the pathogenic mechanism of ventricular arrhythmia by simultaneous optical mapping of membrane potential / calcium transient (CaT) suggested that the mechanism due to the triggered activity due to the increasing difference in APD from the CAT duration.

Free Research Field

不整脈

Academic Significance and Societal Importance of the Research Achievements

急増する心不全パンデミックのうち約半数は左室駆出率が保持されたいわゆるHFpEFであることが報告されている。一方HFpEF患者のうち、虚血性心疾患の合併が多くみられ、そのうちある一定の頻度で突然死が生じることが知られている。突然死のうちほとんどの症例は心室性不整脈であることが想定されている。そのため、HFpEF患者における虚血条件において心室性不整脈の発症機序を明らかにすること、また心室性不整脈に効果的である薬剤の研究は社会的に非常に意義が大きいと考える。