2020 Fiscal Year Final Research Report
The contribution of microglia-mediated brain inflammation to cancer cachexia
Project/Area Number |
19K17604
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 53020:Cardiology-related
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Research Institution | Kyushu University |
Principal Investigator |
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Project Period (FY) |
2019-04-01 – 2021-03-31
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Keywords | 癌カヘキシー / ミクログリア |
Outline of Final Research Achievements |
Cancer cachexia is a state of involuntary weight loss, muscle wasting, and severe malnutrition. Browning of adipocytes and anorexia are major contributors to cancer cachexia through increasing thermogenesis-induced energy consumption and decreasing food intake. Increased neural activity of hypothalamic paraventricular nucleus (PVN) is involved in sympathoexcitation causing the browning of adipocytes. Stimulation of pro-opiomelanocortin (POMC) neurons in arcuate nucleus (ARC) of hypothalamus negatively regulates feeding. Interestingly, activation of microglia can be associated with activity of PVN and POMC neurons. In this study, we used the cancer cachexia model and demonstrated that microglia contribute to cancer cachexia and cardiac wasting through affecting sympathoexcitatory PVN neurons and anorexigenic POMC neurons.
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Free Research Field |
循環器内科学
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Academic Significance and Societal Importance of the Research Achievements |
癌の進行に伴う心機能障害やカヘキシーは、生命予後やQOLに直結するにもかかわらず、その機序は不明であり有効な治療法が確立されていない。本研究により、癌における心機能障害やカヘキシーに対する脳内ミクログリアの役割を新たに証明したことで、その予防・治療法の開発につながることが期待される。
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