2022 Fiscal Year Final Research Report
Environmental risk factors for polycystic liver in Autosomal Dominant Polycystic Kidney Disease and risk classification
| Project/Area Number |
19K17758
|
|---|
| Research Category |
Grant-in-Aid for Early-Career Scientists
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
Basic Section 53040:Nephrology-related
|
|---|
| Research Institution | Okinaka Memorial Institute for Medical Research |
|---|
Principal Investigator |
Suwabe Tatsuya (財)冲中記念成人病研究所, その他部局等, 研究員 (90425439)
|
|---|
| Project Period (FY) |
2019-04-01 – 2023-03-31
|
| Keywords | 多発性嚢胞腎 / 多発性嚢胞肝 / 環境因子 / ADPKD / PLD / polycystic kidney / polycystic liver disease / environmental factors |
|---|
| Outline of Final Research Achievements |
The factors which influence liver volume (LV) in ADPKD are unknown. We revealed that the total kidney volume (TKV) increased until dialysis initiation and generally decreased after dialysis initiation. The LV continued to increase even after dialysis initiation, however, changes in the LV significantly decreased after dialysis initiation. The increases in TKV and LV were greater in patients on PD than in those on HD.
We also investigated the association between Pulse Wave Velocity (PWV) and change in kidney and liver volume in ADPKD. The value of PWV was correlated with total kidney and liver volume. We also investigated factors which influence the changes in LV after renal transcatheter arterial embolization (TAE). The changes in body fluid volume before and 1 year after renal TAE were correlated with reduction rate of LV.
These results suggested that factors associated with artery stiffness such as blood pressure and volume overload may affect the progression of LD in ADPKD.
|
| Free Research Field |
腎臓内科
|
| Academic Significance and Societal Importance of the Research Achievements |
常染色体優性多発性嚢胞腎(ADPKD)患者の腫大腎については、環境因子の重要性が認知され、幾つかの治療方法が確立されてきた。しかし、ADPKD患者に高率に合併する多発性嚢胞肝の腫大については、進行に影響する因子や有効な治療方法は全く確立されていない。著明な腫大肝の患者は、最終的には肝移植しか治療方法がない状況である。本研究により、多発性嚢胞肝においても、多発性嚢胞腎と同様に環境因子が重要であることが明らかになった。ADPKD患者に伴う腫大肝の進行に影響する予後因子がある程度、同定され、進行の予測因子も分かってきた。この研究結果は、多発性嚢胞肝の基本的な管理方法を大きく変える可能性がある。
|
