Function of primary cilia in skin homeostasis

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K17797
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53050:Dermatology-related
• Research Institution: Nara Institute of Science and Technology
• Principal Investigator: Toriyama Manami 奈良先端科学技術大学院大学, 先端科学技術研究科, 助教 (30773121)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 一次繊毛 / アトピー性皮膚炎 / 炎症 / ランゲルハンス細胞 / ケラチノサイト

Outline of Final Research Achievements

In this research, I found that primary cilia, working as signal sensor, were significantly increased in atopic dermatitis epidermis. Over-formation of primary cilia in epidermis increased immature epidermal cells, which led skin barrier disruption and chemokine secretion, and exacerbated the disease. We reported our results in international journal. In addition, we submitted to another international journal, and it is currently resubmitted the revision. We also reported review article in international journal. I presented our results in domestic conference as symposiast. I won 'Best young researcher award' in domestic conference.

Free Research Field

薬理学、細胞生物学、免疫学

Academic Significance and Societal Importance of the Research Achievements

アトピー性皮膚炎の治療は、ステロイド薬等を用いた対症療法のみが存在する。その治療法は有効ではあるものの、発症原因が不確定であるため、再発を繰り返すことが多い。本研究では、アトピー性皮膚炎の発症に一次繊毛が関わる可能性を見出した。一次繊毛の研究歴史は浅く、一次繊毛をターゲットとした創薬はいまだ実現していないため、本研究は新たな作用機序を示す新規薬を開発するための礎となりうる研究である。