Elucidation of the mechanisms by which plasmacytoid dendritic cells activation is regulated in skin diseases

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K17818
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53050:Dermatology-related
• Research Institution: Juntendo University
• Principal Investigator: Kaitani Ayako 順天堂大学, 大学院医学研究科, 特任助教 (50833604)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 免疫受容体 / プラズマサイトイド樹状細胞 / 皮膚炎症

Outline of Final Research Achievements

Loss of an activating receptor leukocyte mono-immunoglobulin-like receptor 8 (LMIR8), specifically expressed in plasmacytoid dendritic cells, failed to influence their activation by Toll-like receptor 7 (TLR7) or TLR9 ligand. In addition, loss of LMIR8 did not significantly influence skin inflammation in TLR7 ligand-applied mice. To examine whether the lipids such as ceramides and phosphatidylserine act as LMIR8 ligands, we performed the binding and reporter assays using an extracellular domain of LMIR8; however, we were not able to identify LMIR8 ligands during the research period.

Free Research Field

炎症

Academic Significance and Societal Importance of the Research Achievements

本研究により、プラズマサイトイド樹状細胞特異的に発現する受容体LMIR8が既知の刺激によるプラズマサイトイド樹状細胞の活性化や皮膚炎症を制御しないことが判明した。本研究成果は、プラズマサイトイド樹状細胞の活性化制御による（炎症性疾患に対する）治療法開発の基礎となり、学術的意義及び社会的意義があると考えられる。