Exploratory study of biomarkers for the development of lifestyle-related diseases by steroid metabolomics analysis

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K17956
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 54040:Metabolism and endocrinology-related
• Research Institution: Kanazawa University
• Principal Investigator: Karashima Shigehiro 金沢大学, GS教育系, 助教 (30801584)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: ステロイド

Outline of Final Research Achievements

Hypertension causes stroke, heart disease, and kidney disease. Hypertension is classified into two groups: salt-sensitive hypertension, in which blood pressure improves with salt reduction, and salt-resistant hypertension, in which blood pressure does not. We compared the composition of the gut microbiota and the prevalence of hypertension in 242 general residents, and found that the prevalence of hypertension in the group of patients with gut microbiota low in Bifidobacterium was similar to that in the group with high salt intake, even with low salt intake. In particular, there was a strong tendency to be associated with B. bifidum and B. breve, and steroid metabolomics analysis suggested involvement with some mineralocorticoids. To further elucidate the mechanism of salt-sensitive hypertension, we plan to conduct additional metagenomic analysis and transplantation experiments into animal models.

Free Research Field

内分泌代謝学

Academic Significance and Societal Importance of the Research Achievements

腸内細菌叢―代謝ネットワークを介した食塩感受性高血圧の発症機序の解明後、食塩感受性高血圧の診断バイオマーカーとしての腸内細菌叢の構成比や細菌叢由来代謝物の有用性を臨床的示し食塩感受性の個体差を考慮した精密医療へつなげることが次の展開と考えている。心血管イベントの発症しやすい食塩感受性高血圧の早期診断やプロバイオティクス、プレバイオティクスによる治療介入を行うことで、日本の国民病ともいうべき高血圧の新しい診療アプローチに繋がり、最終的には、心血管イベントを抑制し現代人の健康寿命の延伸に貢献する可能性がある。