Prevention of liver carcinogenesis in bariatric surgery

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K18028
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55010:General surgery and pediatric surgery-related
• Research Institution: The University of Tokushima
• Principal Investigator: KASHIHARA Hideya 徳島大学, 病院, 特任助教 (10548738)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: Bariatric surgery / 腸内細菌叢 / 肝発癌 / 肥満 / 2型糖尿病 / NASH

Outline of Final Research Achievements

The aim of this study was to investigate prevention of liver carcinogenesis in bariatric surgery. Methods; (1) Obese diabetic rats were divided into bariatric surgery (DJB) group　and sham group. At postoperative 8 weeks, gut microbiome, gut inflammatory cytokines, claudin-1 and tumor counts in liver were investigated. (2) Obese diabetic rats were divided into bariatric surgery group (DJB) and sham group. After the operation, rats drunk DEN mixed water for 15 weeks. Tumor counts and size of the liver in two groups were investigated. Results; (1) DJB group showed increase of Proteobacteria. DJB group showed lower gut inflammation and maintenance of gut permeability. There was no tumor in the two groups. (2) Regarding liver tumor, there was no significant difference in the two groups. Conclusion; Bariatric surgery suppressed systemic inflammation through suppression of gut inflammation and maintenance of gut permeability. Bariatric surgery may prevent inflammation induced carcinogenesis.

Free Research Field

消化器外科学、肥満外科学

Academic Significance and Societal Importance of the Research Achievements

本研究を行う上で、DJBが腸内細菌叢microbiotaにどのように影響を及ぼしているのか、またこのmicrobiotaの変化がどのように2型糖尿病・NASH・肝発癌に影響しているかを検討することは極めて重要となってくるが、これが判明した際には、これまで内科的治療では到底改善できなかった肥満・糖尿病・NASHやそれらに関連する疾患や発癌に対する治療アプローチが一変する可能性がある。