The investigation into the mechanism of tissue auto-fluorescence and developement of new surgical technique

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K18060
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55010:General surgery and pediatric surgery-related
• Research Institution: Kagoshima University
• Principal Investigator: Shinden Yoshiaki 鹿児島大学, 医歯学域鹿児島大学病院, 助教 (20725733)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 自家蛍光 / 副甲状腺 / 手術手技

Outline of Final Research Achievements

In this study, we planned 1; measurement of autofluorescence in human tissues, organs, and various cancer tissues, 2; discovery of the causative agent of new autofluorescence and exploration of its biological significance, 3; building new imaging methods using autofluorescence and establish new surgical methods. particularly, we studied the autofluorescence of the parathyroid glands. Although autofluorescence of the parathyroid gland has been discovered in recent years, its causative agent is unknown, while it is useful for detecting the parathyroid gland during surgery. First, in order to identify autofluorescent substances in the parathyroid glands, we succeeded to find several candidate causative substances by performing protein analysis between parathyroid glands with different fluorescence intensities. We continue to attempt to determine the causative agent by gene expression experiments using cell lines.

Free Research Field

内分泌外科

Academic Significance and Societal Importance of the Research Achievements

本研究を基盤として、新しい手術手技を考案すること患者にとって手術の安全性が向上し、医療従事者にとっては手術の難易度が低下することが期待される。また、新たな医療機器を開発することで科学技術の向上にも寄与する可能性がある。新たな自家蛍光物質が同定されることで、他の臓器でも同様の手法が使用できれば、副甲状腺に限らない、より多くの疾患の治療に貢献できる可能性もある。