An improvement of graft survival by visualization of transplanted pancreatic islets using in vivo imaging system

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K18108
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55020:Digestive surgery-related
• Research Institution: Niigata University
• Principal Investigator: Miura Kohei 新潟大学, 医歯学系, 助教 (70733658)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 膵島移植 / ICG蛍光法 / IRIシステム / 生検 / 拒絶反応 / ブタ

Outline of Final Research Achievements

In this study, it was found that by staining islets to be transplanted with fluorescent dyes in advance, it could be possible to easily identify the site of transplanted islets to perform the biopsy. This makes it possible to diagnose rejection after islet transplantation, which has been impossible until now. The diagnosis of rejection will enable prompt therapeutic intervention, which may improve the transplanted islet's survival rate and long-term independent from insulin therapy.

Free Research Field

肝胆膵・移植外科

Academic Significance and Societal Importance of the Research Achievements

本研究成果により、膵臓移植にかわる低侵襲な根治治療として発展してきた膵島移植の成績が向上し、より多くの糖尿病患者の病状改善に寄与することが期待される。また、蛍光色素で標識された細胞を移植しその機能を視覚化するという発想が、膵島移植以外の細胞治療にも応用される可能性がある。