Basic experimental elucidation of the mechanism of the effect of hydrogen gas on reducing surgical invasion in cardiovascular surgery

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K18189
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55030:Cardiovascular surgery-related
• Research Institution: Nagoya City University
• Principal Investigator: Yamada Toshiyuki 名古屋市立大学, 医薬学総合研究院(医学), 助教 (10728299)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 水素

Outline of Final Research Achievements

We have started to identify the reactivity of inflammatory substances by real-time PCR and immunostaining after collecting adipocytes from patients with cardio-vascular disease with or without atherosclerosis and adding hydrogen to their tissues.Although the number of samples is still small and no significant differences have been observed, the real-time PCR showed that hydrogen may have an anti-inflammatory effect, and the immunostaining showed that the anti-inflammatory effect of hydrogen was remarkable.
By increasing the number of samples in the future, we hope to prove the anti-inflammatory effect of hydrogen on cardiovascular diseases and surgical invasion, and to use this as a basis for postoperative hydrogen inhalation therapy.

Free Research Field

心臓血管外科

Academic Significance and Societal Importance of the Research Achievements

今後、本研究はデータ数を増やして結果を積み重ねることで、水素の循環器疾患・手術侵襲に対する抗炎症作用が証明されることが期待される。さらにこれらの知見を元にして、心臓血管外科手術の周術期の水素吸入療法へとつなげられたらと考えている。水素吸入は非常に簡便に施行可能であるために、実際の臨床現場への応用はそれほど困難なものではないと考えている。