2022 Fiscal Year Final Research Report
Examination of postoperative cognitive dysfunction in obese model mice -Mechanism and its prevention-
Project/Area Number |
19K18257
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 55050:Anesthesiology-related
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Research Institution | Hokkaido University |
Principal Investigator |
Uchida Yosuke 北海道大学, 大学病院, 准教授 (00507585)
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Project Period (FY) |
2019-04-01 – 2023-03-31
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Keywords | 術後認知機能障害 / 肥満 |
Outline of Final Research Achievements |
We investigated the effects of surgery and anesthesia on neuroinflammation and cognitive function in the high-fat diet-induced obese mice. As a result, leptin, a type of adipocytokine, was increased in the high-fat diet-induced obese mice as previously reported. Surgery increased inflammatory cytokines in the hippocampus and enhanced neuroinflammation in the high-fat diet-induced obese mice. However, behavioral tests failed to detect postoperative cognitive impairment. On the other hand, in the group receiving only general anesthesia, neuroinflammation tended to increase, and behavioral tests showed a significant decline in cognitive function.
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Free Research Field |
麻酔学
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Academic Significance and Societal Importance of the Research Achievements |
安全な手術医療を提供することは、周術期医療に携わる医療者にとって最大の使命である。手術後に認知機能が低下しやすい患者群として、高齢や肥満などがリスクファクターとなることが分かっているものの、その機序には不明な点が多く医療者を悩ませている現状がある。本研究は高脂肪食誘発肥満マウスを用いた基礎実験によって、そのリスクの機序を解明し、術後認知機能低下の予防や治療につながる糸口を発見することを目的とした。
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