2022 Fiscal Year Final Research Report
Development of a Novel Treatment for Drug-Induced Liver Injury by Hydrogen Gas Inhalation Therapy and Elucidation of Its Mechanism
Project/Area Number |
19K18359
|
Research Category |
Grant-in-Aid for Early-Career Scientists
|
Allocation Type | Multi-year Fund |
Review Section |
Basic Section 55060:Emergency medicine-related
|
Research Institution | Kagoshima University |
Principal Investigator |
|
Project Period (FY) |
2019-04-01 – 2023-03-31
|
Keywords | 水素ガス / アセトアミノフェン / 薬剤性肝障害 / 中毒 |
Outline of Final Research Achievements |
The effect of hydrogen gas inhalation on acetaminophen (APAP) hepatotoxicity was tested using a model in which APAP 300 mg/kg was administered after a 16-hour fast. Hydrogen gas (a mixture of 1.29% H2 and 21% O2 based on N2) and control gas (a mixture of 79% N2 and 21% O2) were inhaled for 2 hours after APAP administration, and the organ protective effects were evaluated 24 hours later. There was no difference in GSH between the two groups. Further validation of the model, such as the severity of the disease and the combination of the model with existing drugs, is under consideration.
|
Free Research Field |
救急医学
|
Academic Significance and Societal Importance of the Research Achievements |
アセトアミノフェン(APAP)中毒による肝障害に対してはNアセチルシステインによる治療法が確立されているが、頻回投与や味の問題、内服後から治療介入までの時間的制約などいくつかの問題点が残っている。近年、さまざまな臓器障害に対して保護効果が報告されている水素ガス吸入療法をAPAP中毒にも応用する有効性について評価したが、有意な差はみられなかった。モデルの条件変更や既存治療法との併用療法などさらなる検証を続け、今後の新規治療の開発、水素ガス吸入療法が効果を示すメカニズムの解明をすることで今後の薬剤性肝障害の治療戦略に影響を与える可能性がある。
|