2023 Fiscal Year Final Research Report
Comprehensive control strategies for inflammation and coagulation in ECMO circuit occlusion
Project/Area Number |
19K18360
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 55060:Emergency medicine-related
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Research Institution | Kagoshima University |
Principal Investigator |
Futatsuki Takahiro 鹿児島大学, 医歯学域鹿児島大学病院, 客員研究員 (30728184)
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Project Period (FY) |
2019-04-01 – 2024-03-31
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Keywords | ECMO / 回路閉塞 / 炎症 / 凝固 |
Outline of Final Research Achievements |
Extracorporeal membrane oxygenation (ECMO) may be used to provide respiratory and circulatory support for severe respiratory and circulatory failure. A fatal complication of this process is circuit occlusion due to intra-circuit coagulation, but the mechanism is not fully understood. In this study, we found an increase in high mobility group box 1 (HMGB1), one of the damage associated molecular patterns (DAMPs) that induce inflammation, and dihydrobiopterin (BH2), which is associated with vascular endothelial cell damage. In the future, the impact on circuit blockage and measures to control it should be studied.
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Free Research Field |
救急集中治療
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Academic Significance and Societal Importance of the Research Achievements |
COVID-19感染症などで重篤な呼吸循環不全に至った場合、体外式膜型人工肺(extracorporeal membrane oxygenation : ECMO)を用いて、呼吸・循環補助を行うことがある。ECMO管理において、生命予後を左右する問題として回路関連合併症があり、その中でも回路内凝血は最も多い合併症である。回路内凝血の原因として、従来想定されていた血小板や凝固因子以外に、炎症の関与が示唆されており、このメカニズムを解明し、制御することにより、ECMO管理中の致死的合併症を防ぐことができる。
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