Proposal of a new treatment protocol using a flow diverter for large cerebral aneurysms

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K18384
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: Kyoto University (2020); Kanazawa University (2019)
• Principal Investigator: Nambu Iku 京都大学, 医学研究科, 特定病院助教 (80735465)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 脳動脈瘤 / 数値流体解析 / 4D flow MRI

Outline of Final Research Achievements

Computational fluid dynamics (CFD) analysis for cerebral aneurysms is widespread, but it is uncertain whether it reflects actual hemodynamics. This time, we evaluated the validity of CFD analysis by comparing 4D flow MRI, which can measure actual blood flow and blood flow velocity, with CFD analysis so far. CFD analysis and 4D flow MRI were performed on 23 unruptured cerebral aneurysms for comparison. The inflow jet pattern, flow rate ratio, and velocity ratio obtained by CFD analysis were significantly correlated with the values obtained by 4D flow MRI, suggesting the validity of CFD analysis.

Free Research Field

脳神経外科

Academic Significance and Societal Importance of the Research Achievements

脳動脈瘤に対する数値流体 (computational fluid dynamics: CFD) 解析は広く行われているが，実際の血行動態を反映しているかどうかは定かではなかった．今回，CFD解析で得られる血行力学因子と，実際の血流量や血流速度を測定することが可能である4D flow MRI で得られる血行力学的因子とを比較し，有意な相関があることが分かった．これまで行われてきたCFD解析の妥当性を証明することができた．